Early reports suggest at least eight people have been killed, with scores injured, in the town of Cizre.
A truck loaded with explosives detonated roughly 50 meters from the town's police station, in Sirnak province, at around 4 a.m (local time). It levelled the checkpoint and appeared to have caused widespread damage.
There are no firm figures on the death toll as yet, but hospital sources told Reuters at least eight people have died and 45 have been injured.
The health ministry dispatched 12 ambulances and two helicopters to the site, the Associated Press reported.
Scattered reports also claimed a gunfight between police officers and the assailants broke out following the explosion, Al Jazeera reported.
There have been no claims of responsibility. However, Turkey's state-affiliated Andalou news agency were quick to place the blame on the banned Kurdistan Workers Party (PKK). The city has been subject to curfews in the past year as Turkish authorities cracked down against the Kurdish group.
Footage purportedly from the scene showed a massive plume of smoke rising over the south-eastern town.
Photographs shared on social media appeared to show a three-storey building in ruins. It has not been possible to verify these images.
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